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The nuclear piston activates mechanosensitive ion channels to generate cell migration paths in confining microenvironments

Cell migration in confining microenvironments is limited by the ability of the stiff nucleus to deform through pores when migration paths are preexisting and elastic, but how cells generate these paths remains unclear. Here, we reveal a mechanism by which the nucleus mechanically generates migration...

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Bibliografiska uppgifter
I publikationen:Sci Adv
Huvudupphovsmän: Lee, Hong-pyo, Alisafaei, Farid, Adebawale, Kolade, Chang, Julie, Shenoy, Vivek B., Chaudhuri, Ovijit
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Association for the Advancement of Science 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793582/
https://ncbi.nlm.nih.gov/pubmed/33523987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd4058
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