Dichlorophenyl piperazines, including a recently-approved atypical antipsychotic, are potent inhibitors of DHCR7, the last enzyme in cholesterol biosynthesis

While antipsychotic medications provide important relief from debilitating psychotic symptoms, they also have significant adverse side effects, which might have relevant impact on human health. Several research studies, including ours, have shown that commonly used antipsychotics such as haloperidol...

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Udgivet i:Toxicol Appl Pharmacol
Main Authors: Genaro-Mattos, Thiago C., Tallman, Keri A., Allen, Luke B., Anderson, Allison, Mirnics, Karoly, Korade, Zeljka, Porter, Ned A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685688/
https://ncbi.nlm.nih.gov/pubmed/29698737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2018.04.029
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