Maternal aripiprazole exposure interacts with 7-dehydrocholesterol reductase mutations and alters embryonic neurodevelopment

Mutations in both copies in the gene encoding 7-dehydrocholesterol reductase (DHCR7) cause Smith–Lemli–Opitz Syndrome (SLOS), which is characterized by a toxic elevation in 7-dehydrocholesterol (7-DHC). Aripiprazole (ARI) exposure, independent of genetic mutations, also leads to elevation of 7-DHC....

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Udgivet i:Mol Psychiatry
Main Authors: Genaro-Mattos, Thiago C., Allen, Luke B., Anderson, Allison, Tallman, Keri A., Porter, Ned A., Korade, Zeljka, Mirnics, Károly
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Immediate Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477890/
https://ncbi.nlm.nih.gov/pubmed/30742019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-019-0368-6
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