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Intracellular Ca(2+) Homeostasis and Nuclear Export Mediate Exit from Naive Pluripotency

Progression through states of pluripotency is required for cells in early mammalian embryos to transition away from heightened self-renewal and toward competency for lineage specification. Here, we use a CRISPR mutagenesis screen in mouse embryonic stem cells (ESCs) to identify unexpected roles for...

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Détails bibliographiques
Publié dans:Cell Stem Cell
Auteurs principaux: MacDougall, Matthew S., Clarke, Ryan, Merrill, Bradley J.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685429/
https://ncbi.nlm.nih.gov/pubmed/31104942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.04.015
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