Ca(2+)-Dependent Nuclear Export Mediated by Calreticulin

We have characterized a pathway for nuclear export of the glucocorticoid receptor (GR) in mammalian cells. This pathway involves the Ca(2+) -binding protein calreticulin (CRT), which directly contacts the DNA binding domain (DBD) of GR and facilitates its delivery from the nucleus to the cytoplasm....

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Main Authors: Holaska, James M., Black, Ben E., Rastinejad, Fraydoon, Paschal, Bryce M.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2002
主題:
Nucleocytoplasmic Communication
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC133999/
https://ncbi.nlm.nih.gov/pubmed/12167720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.17.6286-6297.2002
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