Steady-State Nuclear Localization of Exportin-t Involves RanGTP Binding and Two Distinct Nuclear Pore Complex Interaction Domains

Vertebrate tRNA export receptor exportin-t (Xpo-t) binds to RanGTP and mature tRNAs cooperatively to form a nuclear export complex. Xpo-t shuttles bidirectionally through nuclear pore complexes (NPCs) but is mainly nuclear at steady state. The steady-state distribution of Xpo-t is shown to depend on...

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Detalhes bibliográficos
Main Authors: Kuersten, Scott, Arts, Gert-Jan, Walther, Tobias C., Englmeier, Ludwig, Mattaj, Iain W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Nucleocytoplasmic Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133969/
https://ncbi.nlm.nih.gov/pubmed/12138183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.16.5708-5720.2002
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