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KLF4 Nuclear Export Requires ERK Activation and Initiates Exit from Naive Pluripotency
Cooperative action of a transcription factor complex containing OCT4, SOX2, NANOG, and KLF4 maintains the naive pluripotent state; however, less is known about the mechanisms that disrupt this complex, initiating exit from pluripotency. We show that, as embryonic stem cells (ESCs) exit pluripotency,...
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| Publicado no: | Stem Cell Reports |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6000723/ https://ncbi.nlm.nih.gov/pubmed/29526737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.02.007 |
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