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Co-incident insertion enables high efficiency genome engineering in mouse embryonic stem cells
CRISPR/Cas9 nucleases have enabled powerful, new genome editing capabilities; however, the preponderance of non-homologous end joining (NHEJ) mediated repair events over homology directed repair (HDR) in most cell types limits the ability to engineer precise changes in mammalian genomes. Here, we in...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5027516/ https://ncbi.nlm.nih.gov/pubmed/27484482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw685 |
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