Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans

Eitemau Tebyg

• Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation
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  Cyhoeddwyd: (2020)
• Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer’s disease
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  Cyhoeddwyd: (2014)
• Crystallization and preliminary X-ray diffraction analysis of tau protein microtubule-binding motifs in complex with Tau5 and DC25 antibody Fab fragments
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  Cyhoeddwyd: (2012)
• First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model
  gan: Kontsekova, Eva, et al.
  Cyhoeddwyd: (2014)
• Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease
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  Cyhoeddwyd: (2010)