Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

BDNF/TrkB neurotrophic signaling regulates neuronal development, differentiation, and survival, and deficient BDNF/TrkB activity underlies neurodegeneration in Alzheimer’s disease (AD). However, exactly how BDNF/TrkB participates in AD pathology remains unclear. Here, we show that deprivation of BDN...

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Pubblicato in:Cell Rep
Autori principali: Wang, Zhi-Hao, Xiang, Jie, Liu, Xia, Yu, Shan Ping, Manfredsson, Fredric P., Sandoval, Ivette M., Wu, Shengxi, Wang, Jian-Zhi, Ye, Keqiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684282/
https://ncbi.nlm.nih.gov/pubmed/31315045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.054
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