Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer

Human guanylate kinase (hGMPK) is the only known enzyme responsible for cellular GDP production, making it essential for cellular viability and proliferation. Moreover, hGMPK has been assigned a critical role in metabolic activation of antiviral and antineoplastic nucleoside-analog prodrugs. Given t...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Khan, Nazimuddin, Shah, Parag P., Ban, David, Trigo-Mouriño, Pablo, Carneiro, Marta G., DeLeeuw, Lynn, Dean, William L., Trent, John O., Beverly, Levi J., Konrad, Manfred, Lee, Donghan, Sabo, T. Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2019
Konular:
Protein Structure and Folding
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682748/
https://ncbi.nlm.nih.gov/pubmed/31201273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009251
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