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Guanylate Kinase, Induced Fit, and the Allosteric Spring Probe
Since the introduction of the induced-fit theory by D. E. Koshland Jr., it has been established that conformational motion invariably accompanies the execution of protein function. The catalytic activity of kinases, specifically, is associated with large conformational changes (∼1 nm amplitude). In...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Biophysical Society
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1796832/ https://ncbi.nlm.nih.gov/pubmed/17142284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.092866 |
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