Enzyme Closure and Nucleotide Binding Structurally Lock Guanylate Kinase

We investigate the conformational dynamics and mechanical properties of guanylate kinase (GK) using a multiscale approach combining high-resolution atomistic molecular dynamics and low-resolution Brownian dynamics simulations. The GK enzyme is subject to large conformational changes, leading from an...

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Bibliographic Details
Main Authors: Delalande, Olivier, Sacquin-Mora, Sophie, Baaden, Marc
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2011
Subjects:
Protein
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177050/
https://ncbi.nlm.nih.gov/pubmed/21943425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.07.048
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