Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer

Human guanylate kinase (hGMPK) is the only known enzyme responsible for cellular GDP production, making it essential for cellular viability and proliferation. Moreover, hGMPK has been assigned a critical role in metabolic activation of antiviral and antineoplastic nucleoside-analog prodrugs. Given t...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Khan, Nazimuddin, Shah, Parag P., Ban, David, Trigo-Mouriño, Pablo, Carneiro, Marta G., DeLeeuw, Lynn, Dean, William L., Trent, John O., Beverly, Levi J., Konrad, Manfred, Lee, Donghan, Sabo, T. Michael
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Protein Structure and Folding
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682748/
https://ncbi.nlm.nih.gov/pubmed/31201273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009251
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