Sublinear response in lacZ mutant frequency of Muta(™)Mouse spermatogonial stem cells after low dose subchronic exposure to N‐ethyl‐N‐nitrosourea

The transgenic rodent mutation assay was used to compare the dose–response relationship of lacZ mutant frequency (MF) in spermatogonial stem cells exposed acutely or subchronically to N‐ethyl‐N‐nitrosourea (ENU). Muta(™)Mouse males were exposed orally to 0, 25, 50, or 100 mg/kg ENU for acute exposur...

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Detalhes bibliográficos
Publicado no:Environ Mol Mutagen
Main Authors: O'Brien, Jason M., Walker, Mike, Sivathayalan, Ahalya, Douglas, George R., Yauk, Carole L., Marchetti, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680333/
https://ncbi.nlm.nih.gov/pubmed/25598316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.21932
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