Sublinear response in lacZ mutant frequency of Muta(™)Mouse spermatogonial stem cells after low dose subchronic exposure to N‐ethyl‐N‐nitrosourea

The transgenic rodent mutation assay was used to compare the dose–response relationship of lacZ mutant frequency (MF) in spermatogonial stem cells exposed acutely or subchronically to N‐ethyl‐N‐nitrosourea (ENU). Muta(™)Mouse males were exposed orally to 0, 25, 50, or 100 mg/kg ENU for acute exposur...

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Publicado en:Environ Mol Mutagen
Autores principales: O'Brien, Jason M., Walker, Mike, Sivathayalan, Ahalya, Douglas, George R., Yauk, Carole L., Marchetti, Francesco
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2015
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680333/
https://ncbi.nlm.nih.gov/pubmed/25598316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.21932
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