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Benzo(a)pyrene Is Mutagenic in Mouse Spermatogonial Stem Cells and Dividing Spermatogonia

Although many environmental agents are established male germ cell mutagens, few are known to induce mutations in spermatogonial stem cells. Stem cell mutations are of great concern because they result in a permanent increase in the number of mutations carried in sperm. We investigated mutation induc...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: O’Brien, Jason M., Beal, Marc A., Yauk, Carole L., Marchetti, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4960908/
https://ncbi.nlm.nih.gov/pubmed/27208087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw088
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