Induction of lacZ Mutations in Muta™Mouse Primary Hepatocytes

We have developed an in vitro mutation assay using primary hepatocytes from the transgenic Muta™Mouse. Primary hepatocytes were isolated using a two-step perfusion method with purification by Percoll, cultured, and treated with benzo[a]pyrene (BaP), 2-amino-1-methyl-6-phenyl- imidazo[4,5-b]pyridine...

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Библиографические подробности
Главные авторы: Chen, Guosheng, Gingerich, John, Soper, Lynda, Douglas, George R, White, Paul A
Формат: Artigo
Язык:Inglês
Опубликовано: Wiley Subscription Services, Inc., A Wiley Company 2010
Предметы:
Brief Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2959491/
https://ncbi.nlm.nih.gov/pubmed/19953605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.20540
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