Simultaneous Measurement of Benzo[a]pyrene-induced Pig-a and lacZ Mutations, Micronuclei and DNA Adducts in Muta™ Mouse

In this study we compared the response of the Pig-a gene mutation assay to that of the lacZ transgenic rodent mutation assay, and demonstrated that multiple endpoints can be measured in a 28-day repeat dose study. Muta™Mouse were dosed daily for 28 days with benzo[a]pyrene (BaP; 0, 25, 50 and 75 mg/...

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Main Authors: Lemieux, Christine L, Douglas, George R, Gingerich, John, Phonethepswath, Souk, Torous, Dorothea K, Dertinger, Stephen D, Phillips, David H, Arlt, Volker M, White, Paul A
Format: Artigo
Jezik:Inglês
Izdano: Wiley Subscription Services, Inc., A Wiley Company 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258540/
https://ncbi.nlm.nih.gov/pubmed/21976233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.20688
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