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Integrated In Vivo Genotoxicity Assessment of Procarbazine Hydrochloride Demonstrates Induction of Pig‐a and LacZ Mutations, and Micronuclei, in MutaMouse Hematopoietic Cells

Procarbazine hydrochloride (PCH) is a DNA‐reactive hematopoietic carcinogen with potent and well‐characterized clastogenic activity. However, there is a paucity of in vivo mutagenesis data for PCH, and in vitro assays often fail to detect the genotoxic effects of PCH due to the complexity of its met...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Environ Mol Mutagen
Hauptverfasser: Maurice, Clotilde, Dertinger, Stephen D., Yauk, Carole L., Marchetti, Francesco
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Inc. 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618172/
https://ncbi.nlm.nih.gov/pubmed/30592561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22271
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