Chemically induced mutations in a MutaMouse reporter gene inform mechanisms underlying human cancer mutational signatures

Transgenic rodent (TGR) models use bacterial reporter genes to quantify in vivo mutagenesis. Pairing TGR assays with next-generation sequencing (NGS) enables comprehensive mutation pattern analysis to inform mutational mechanisms. We used this approach to identify 2751 independent lacZ mutations in...

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Publicado en:Commun Biol
Autores principales: Beal, Marc A., Meier, Matthew J., LeBlanc, Danielle P., Maurice, Clotilde, O’Brien, Jason M., Yauk, Carole L., Marchetti, Francesco
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429849/
https://ncbi.nlm.nih.gov/pubmed/32796912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01174-y
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