Sublinear response in lacZ mutant frequency of Muta(™)Mouse spermatogonial stem cells after low dose subchronic exposure to N‐ethyl‐N‐nitrosourea

The transgenic rodent mutation assay was used to compare the dose–response relationship of lacZ mutant frequency (MF) in spermatogonial stem cells exposed acutely or subchronically to N‐ethyl‐N‐nitrosourea (ENU). Muta(™)Mouse males were exposed orally to 0, 25, 50, or 100 mg/kg ENU for acute exposur...

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Bibliografiske detaljer
Udgivet i:Environ Mol Mutagen
Main Authors: O'Brien, Jason M., Walker, Mike, Sivathayalan, Ahalya, Douglas, George R., Yauk, Carole L., Marchetti, Francesco
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680333/
https://ncbi.nlm.nih.gov/pubmed/25598316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.21932
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