Molecular basis for the binding and selective dephosphorylation of Na(+)/H(+) exchanger 1 by calcineurin

Very little is known about how Ser/Thr protein phosphatases specifically recruit and dephosphorylate substrates. Here, we identify how the Na(+)/H(+)-exchanger 1 (NHE1), a key regulator of cellular pH homeostasis, is regulated by the Ser/Thr phosphatase calcineurin (CN). NHE1 activity is increased b...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hendus-Altenburger, Ruth, Wang, Xinru, Sjøgaard-Frich, Lise M., Pedraz-Cuesta, Elena, Sheftic, Sarah R., Bendsøe, Anne H., Page, Rebecca, Kragelund, Birthe B., Pedersen, Stine F., Peti, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677818/
https://ncbi.nlm.nih.gov/pubmed/31375679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11391-7
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