Dynamic Na(+)/H(+) exchanger 1 (NHE1) – calmodulin complexes of varying stoichiometry and structure regulate Ca(2+)-dependent NHE1 activation

Calmodulin (CaM) engages in Ca(2+)-dependent interactions with numerous proteins, including a still incompletely understood physical and functional interaction with the human Na(+)/H(+)-exchanger NHE1. Using nuclear magnetic resonance (NMR) spectroscopy, isothermal titration calorimetry, and fibrobl...

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Udgivet i:eLife
Main Authors: Sjøgaard-Frich, Lise M, Prestel, Andreas, Pedersen, Emilie S, Severin, Marc, Kristensen, Kristian Kølby, Olsen, Johan G, Kragelund, Birthe B, Pedersen, Stine Falsig
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2021
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009664/
https://ncbi.nlm.nih.gov/pubmed/33655882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60889
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