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Molecular basis for the binding and selective dephosphorylation of Na(+)/H(+) exchanger 1 by calcineurin
Very little is known about how Ser/Thr protein phosphatases specifically recruit and dephosphorylate substrates. Here, we identify how the Na(+)/H(+)-exchanger 1 (NHE1), a key regulator of cellular pH homeostasis, is regulated by the Ser/Thr phosphatase calcineurin (CN). NHE1 activity is increased b...
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| Publicat a: | Nat Commun |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6677818/ https://ncbi.nlm.nih.gov/pubmed/31375679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11391-7 |
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