Transient or extended reversal of apixaban anticoagulation by andexanet alfa is equally effective in a porcine polytrauma model()

BACKGROUND: Andexanet alfa (andexanet) reverses the anticoagulant effects of factor Xa inhibitors, but it has not been assessed in clinical studies for apixaban reversal in trauma. This study evaluated andexanet for reversing apixaban anticoagulation in a porcine polytrauma model. METHODS: Oral apix...

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Publicat a:Br J Anaesth
Autors principals: Grottke, Oliver, Braunschweig, Till, Rossaint, Rolf, Akman, Necib, Leeds, Janet M., Conley, Pamela B., Honickel, Markus
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
Matèries:
Critical Care
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676228/
https://ncbi.nlm.nih.gov/pubmed/31202564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2019.04.059
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