Transient or extended reversal of apixaban anticoagulation by andexanet alfa is equally effective in a porcine polytrauma model()

BACKGROUND: Andexanet alfa (andexanet) reverses the anticoagulant effects of factor Xa inhibitors, but it has not been assessed in clinical studies for apixaban reversal in trauma. This study evaluated andexanet for reversing apixaban anticoagulation in a porcine polytrauma model. METHODS: Oral apix...

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Detalles Bibliográficos
Publicado en:Br J Anaesth
Main Authors: Grottke, Oliver, Braunschweig, Till, Rossaint, Rolf, Akman, Necib, Leeds, Janet M., Conley, Pamela B., Honickel, Markus
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2019
Assuntos:
Critical Care
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676228/
https://ncbi.nlm.nih.gov/pubmed/31202564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2019.04.059
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