Transient or extended reversal of apixaban anticoagulation by andexanet alfa is equally effective in a porcine polytrauma model()

BACKGROUND: Andexanet alfa (andexanet) reverses the anticoagulant effects of factor Xa inhibitors, but it has not been assessed in clinical studies for apixaban reversal in trauma. This study evaluated andexanet for reversing apixaban anticoagulation in a porcine polytrauma model. METHODS: Oral apix...

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Bibliografiske detaljer
Udgivet i:Br J Anaesth
Main Authors: Grottke, Oliver, Braunschweig, Till, Rossaint, Rolf, Akman, Necib, Leeds, Janet M., Conley, Pamela B., Honickel, Markus
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Critical Care
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676228/
https://ncbi.nlm.nih.gov/pubmed/31202564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2019.04.059
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