Locus Ceruleus Degeneration Promotes Alzheimer Pathogenesis in Amyloid Precursor Protein 23 Transgenic Mice

Locus ceruleus (LC) degeneration and loss of cortical noradrenergic innervation occur early in Alzheimer’s disease (AD). Although this has been known for several decades, the contribution of LC degeneration to AD pathogenesis remains unclear. We induced LC degeneration with N-(2-chloroethyl)-N-ethyl...

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Publicado no:J Neurosci
Main Authors: Heneka, Michael T., Ramanathan, Mutiah, Jacobs, Andreas H., Dumitrescu-Ozimek, Lucia, Bilkei-Gorzo, Andras, Debeir, Thomas, Sastre, Magdalena, Galldiks, Norbert, Zimmer, Andreas, Hoehn, Mathias, Heiss, Wolf-Dieter, Klockgether, Thomas, Staufenbiel, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675491/
https://ncbi.nlm.nih.gov/pubmed/16452658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4236-05.2006
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