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Locus Ceruleus Degeneration Promotes Alzheimer Pathogenesis in Amyloid Precursor Protein 23 Transgenic Mice

Locus ceruleus (LC) degeneration and loss of cortical noradrenergic innervation occur early in Alzheimer’s disease (AD). Although this has been known for several decades, the contribution of LC degeneration to AD pathogenesis remains unclear. We induced LC degeneration with N-(2-chloroethyl)-N-ethyl...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Heneka, Michael T., Ramanathan, Mutiah, Jacobs, Andreas H., Dumitrescu-Ozimek, Lucia, Bilkei-Gorzo, Andras, Debeir, Thomas, Sastre, Magdalena, Galldiks, Norbert, Zimmer, Andreas, Hoehn, Mathias, Heiss, Wolf-Dieter, Klockgether, Thomas, Staufenbiel, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2006
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675491/
https://ncbi.nlm.nih.gov/pubmed/16452658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4236-05.2006
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