The Voltage-Gated Sodium Channel Na(v)1.9 Is an Effector of Peripheral Inflammatory Pain Hypersensitivity

We used a mouse with deletion of exons 4, 5, and 6 of the SCN11A (sodium channel, voltage-gated, type XI, α) gene that encodes the voltage-gated sodium channel Na(v)1.9 to assess its contribution to pain. Na(v)1.9 is present in nociceptor sensory neurons that express TRPV1, bradykinin B(2), and puri...

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Udgivet i:J Neurosci
Main Authors: Amaya, Fumimasa, Wang, Haibin, Costigan, Michael, Allchorne, Andrew J., Hatcher, Jon P., Egerton, Julie, Stean, Tania, Morisset, Valerie, Grose, David, Gunthorpe, Martin J., Chessell, Iain P., Tate, Simon, Green, Paula J., Woolf, Clifford J.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2006
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674969/
https://ncbi.nlm.nih.gov/pubmed/17167076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4015-06.2006
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