Deficits in Synaptic Transmission and Learning in Amyloid Precursor Protein (APP) Transgenic Mice Require C-Terminal Cleavage of APP

Synaptic dysfunction has been shown to be one of the earliest correlates of disease progression in animal models of Alzheimer's disease. Amyloid-β protein (Aβ) is thought to play an important role in disease-related synaptic dysfunction, but the mechanism by which Aβ leads to synaptic dysfuncti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Saganich, Michael J., Schroeder, Brock E., Galvan, Veronica, Bredesen, Dale E., Koo, Edward H., Heinemann, Stephen F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2006
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674728/
https://ncbi.nlm.nih.gov/pubmed/17192425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4180-06.2006
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