C-Terminal Cleavage of the Amyloid-β Protein Precursor at Asp664: A Switch Associated with Alzheimer's Disease

In addition to the proteolytic cleavages that give rise to amyloid-β (Aβ), the amyloid-β protein precursor (AβPP) is cleaved at Asp664 intracytoplasmically. This cleavage releases a cytotoxic peptide, APP-C31, removes AβPP-interaction motifs required for signaling and internalization, and is require...

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Main Authors: Banwait, Surita, Galvan, Veronica, Zhang, Junli, Gorostiza, Olivia F., Ataie, Marina, Huang, Wei, Crippen, Danielle, Koo, Edward H., Bredesen, Dale E.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818039/
https://ncbi.nlm.nih.gov/pubmed/18334752
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