Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: A role for early experience

In addition to the cleavages that generate amyloid-beta (Aϐ), the Aϐ-precursor protein (APP) is processed at Asp664, releasing a second toxic peptide (APP-C31). Transgenic mice otherwise identical to a well-characterized model of AD, PDAPP mice, but carrying a mutation that obliterates Asp664 show a...

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Hauptverfasser: Zhang, Junli, Gorostiza, Olivia F., Tang, Huidong, Bredesen, Dale E., Galvan, Veronica
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783897/
https://ncbi.nlm.nih.gov/pubmed/19751769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2009.09.013
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