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Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: A role for early experience
In addition to the cleavages that generate amyloid-beta (Aϐ), the Aϐ-precursor protein (APP) is processed at Asp664, releasing a second toxic peptide (APP-C31). Transgenic mice otherwise identical to a well-characterized model of AD, PDAPP mice, but carrying a mutation that obliterates Asp664 show a...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2783897/ https://ncbi.nlm.nih.gov/pubmed/19751769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2009.09.013 |
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