IN VIVO OXIDATIVE STRESS IN BRAIN OF ALZHEIMER DISEASE TRANSGENIC MICE: REQUIREMENT FOR METHIONINE 35 IN AMYLOID β-PEPTIDE OF APP

Numerous studies have demonstrated oxidative damage in the central nervous system in subjects with Alzheimer disease and in animal models of this dementing disorder. In the current study, we show that transgenic mice modeling Alzheimer disease—PDAPP mice with Swedish and Indiana mutations in human a...

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Detalhes bibliográficos
Main Authors: Butterfield, D. Allan, Galvan, Veronica, Lange, Miranda Bader, Tang, Huidong, Sowell, Renã A., Spilman, Patricia, Fombonne, Joanna, Gorostiza, Olivia, Zhang, Junli, Sultana, Rukhsana, Bredesen, Dale E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818480/
https://ncbi.nlm.nih.gov/pubmed/19854267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2009.10.035
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