Ataxin-3 Represses Transcription via Chromatin Binding, Interaction with Histone Deacetylase 3, and Histone Deacetylation

Ataxin-3 (AT3), the disease protein in spinocerebellar ataxia type 3 (SCA3), has been associated with the ubiquitin–proteasome system and transcriptional regulation. Here we report that normal AT3 binds to target DNA sequences in specific chromatin regions of the matrix metalloproteinase-2 (MMP-2) g...

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Pubblicato in:J Neurosci
Autori principali: Evert, Bernd O., Araujo, Julieta, Vieira-Saecker, Ana M., de Vos, Rob A. I., Harendza, Sigrid, Klockgether, Thomas, Wüllner, Ullrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2006
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674535/
https://ncbi.nlm.nih.gov/pubmed/17079677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2053-06.2006
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