Pharmacological Activation of mGlu4 Metabotropic Glutamate Receptors Reduces Nigrostriatal Degeneration in Mice Treated with 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine

We examined whether selective activation of mGlu4 metabotropic glutamate receptors attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage in mice. C57BL mice were treated with a single dose of MPTP (30 mg/kg, i.p.) preceded, 30 min earlier, by a systemic injectio...

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Publicado en:J Neurosci
Autores principales: Battaglia, Giuseppe, Busceti, Carla L., Molinaro, Gemma, Biagioni, Francesca, Traficante, Anna, Nicoletti, Ferdinando, Bruno, Valeria
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2006
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673941/
https://ncbi.nlm.nih.gov/pubmed/16822979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1595-06.2006
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