Single-molecule long-read sequencing reveals the chromatin basis of gene expression

Genome-wide chromatin accessibility and nucleosome occupancy profiles have been widely investigated, while the long-range dynamics remain poorly studied at the single-cell level. Here, we present a new experimental approach, methyltransferase treatment followed by single-molecule long-read sequencin...

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Vydáno v:Genome Res
Hlavní autoři: Wang, Yunhao, Wang, Anqi, Liu, Zujun, Thurman, Andrew L., Powers, Linda S., Zou, Meng, Zhao, Yue, Hefel, Adam, Li, Yunyi, Zabner, Joseph, Au, Kin Fai
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2019
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Method
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673713/
https://ncbi.nlm.nih.gov/pubmed/31201211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.251116.119
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