A Statistical Method for Observing Personal Diploid Methylomes and Transcriptomes with Single-Molecule Real-Time Sequencing

We address the problem of observing personal diploid methylomes, CpG methylome pairs of homologous chromosomes that are distinguishable with respect to phased heterozygous variants (PHVs), which is challenging due to scarcity of PHVs in personal genomes. Single molecule real-time (SMRT) sequencing i...

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Detalhes bibliográficos
Main Authors: Yuta Suzuki, Yunhao Wang, Kin Fai Au, Shinichi Morishita
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-09-01
Colecção:Genes
Assuntos:
statistical methods
DNA methylation
gene expression
single molecule real-time sequencing
allele-specific analysis
Acesso em linha:http://www.mdpi.com/2073-4425/9/9/460
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