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Apoptotic Actions of p53 Require Transcriptional Activation of PUMA and Do Not Involve a Direct Mitochondrial/Cytoplasmic Site of Action in Postnatal Cortical Neurons

Recent studies in non-neuronal cells have shown that the tumor suppressor p53 can promote cell death through a transcription-independent mechanism involving its direct action with a subset of Bcl-2 family member proteins in the cytosol and at the mitochondria. In cultured cortical neurons, however,...

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Detaylı Bibliyografya
Yayımlandı:J Neurosci
Asıl Yazarlar: Uo, Takuma, Kinoshita, Yoshito, Morrison, Richard S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673255/
https://ncbi.nlm.nih.gov/pubmed/17989286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3222-05.2007
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