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Histone Deacetylase Inhibitors Prevent p53-Dependent and p53-Independent Bax-Mediated Neuronal Apoptosis through Two Distinct Mechanisms
Pharmacological manipulation of protein acetylation levels by histone deacetylase (HDAC) inhibitors represents a novel therapeutic strategy to treat neurodegeneration as well as cancer. However, the molecular mechanisms that determine how HDAC inhibition exerts a protective effect in neurons as oppo...
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Main Authors: | , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Society for Neuroscience
2009
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2673506/ https://ncbi.nlm.nih.gov/pubmed/19261878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6186-08.2009 |
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