Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms

Abexinostat is a pan histone deacetylase inhibitor (HDACi) that demonstrates efficacy in malignancy treatment. Like other HDACi, this drug induces a profound thrombocytopenia whose mechanism is only partially understood. We have analyzed its effect at doses reached in patient plasma on in vitro mega...

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Détails bibliographiques
Auteurs principaux: Ali, A, Bluteau, O, Messaoudi, K, Palazzo, A, Boukour, S, Lordier, L, Lecluse, Y, Rameau, P, Kraus-Berthier, L, Jacquet-Bescond, A, Lelièvre, H, Depil, S, Dessen, P, Solary, E, Raslova, H, Vainchenker, W, Plo, I, Debili, N
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730430/
https://ncbi.nlm.nih.gov/pubmed/23887629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.260
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