Treatment of Nasopharyngeal Carcinoma Cells with the Histone-Deacetylase Inhibitor Abexinostat: Cooperative Effects with Cis-platin and Radiotherapy on Patient-Derived Xenografts

EBV-related nasopharyngeal carcinomas (NPCs) still raise serious therapeutic problems. The therapeutic potential of the histone-deacetylase (HDAC) inhibitor Abexinostat was investigated using 5 preclinical NPC models including 2 patient-derived xenografts (C15 and C17). The cytotoxicity of Abexinost...

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Hauptverfasser: Gressette, Mélanie, Vérillaud, Benjamin, Jimenez-Pailhès, Anne-Sophie, Lelièvre, Hélène, Lo, Kwok-Wai, Ferrand, François-Régis, Gattolliat, Charles-Henry, Jacquet-Bescond, Anne, Kraus-Berthier, Laurence, Depil, Stéphane, Busson, Pierre
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949989/
https://ncbi.nlm.nih.gov/pubmed/24618637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091325
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