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p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity

p53's apoptotic program consists of transcription-dependent and transcription-independent pathways. In the latter, physical interactions between mitochondrial p53 and anti- and pro-apoptotic members of the Bcl2 family of mitochondrial permeability regulators are central. Using isogenic cell sys...

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Détails bibliographiques
Auteurs principaux: Wolff, Sonja, Erster, Susan, Palacios, Gustavo, Moll, Ute M
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830652/
https://ncbi.nlm.nih.gov/pubmed/18504456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2008.62
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