In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation

p53 promotes apoptosis in response to death stimuli by transactivation of target genes and by transcription-independent mechanisms. We recently showed that wild-type p53 rapidly translocates to mitochondria in response to multiple death stimuli in cultured cells. Mitochondrial p53 physically interac...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Erster, Susan, Mihara, Motohiro, Kim, Roger H., Petrenko, Oleksi, Moll, Ute M.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2004
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC444865/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15254240/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.15.6728-6741.2004
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