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E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression
To better understand the role of E2F1 in tumor formation, we analyzed spontaneous tumorigenesis in p53(−/−)E2F1(+/+) and p53(−/−)E2F1(−/−) mice. We show that the combined loss of p53 and E2F1 leads to an increased incidence of sarcomas and carcinomas compared to the loss of p53 alone. E2F1-deficient...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4012429/ https://ncbi.nlm.nih.gov/pubmed/18583939 |
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