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E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression

To better understand the role of E2F1 in tumor formation, we analyzed spontaneous tumorigenesis in p53(−/−)E2F1(+/+) and p53(−/−)E2F1(−/−) mice. We show that the combined loss of p53 and E2F1 leads to an increased incidence of sarcomas and carcinomas compared to the loss of p53 alone. E2F1-deficient...

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Detalhes bibliográficos
Main Authors: Palacios, Gustavo, Talos, Flaminia, Nemajerova, Alice, Moll, Ute M., Petrenko, Oleksi
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012429/
https://ncbi.nlm.nih.gov/pubmed/18583939
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