The Membrane Attack Complex of the Complement System Is Essential for Rapid Wallerian Degeneration

The complement (C) system plays an important role in myelin breakdown during Wallerian degeneration (WD). The pathway and mechanism involved are, however, not clear. In a crush injury model of the sciatic nerve, we show that C6, necessary for the assembly of the membrane attack complex (MAC), is ess...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Ramaglia, Valeria, King, Rosalind Helen Mary, Nourallah, Michelle, Wolterman, Ruud, de Jonge, Rosalein, Ramkema, Marja, Vigar, Miriam Ann, van der Wetering, Sandra, Morgan, Brian Paul, Troost, Dirk, Baas, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2007
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672891/
https://ncbi.nlm.nih.gov/pubmed/17634361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5623-06.2007
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