Soluble Complement Receptor 1 Protects the Peripheral Nerve from Early Axon Loss after Injury

Complement activation is a crucial early event in Wallerian degeneration. In this study we show that treatment of rats with soluble complement receptor 1 (sCR1), an inhibitor of all complement pathways, blocked both systemic and local complement activation after crush injury of the sciatic nerve. De...

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Detalhes bibliográficos
Main Authors: Ramaglia, Valeria, Wolterman, Ruud, de Kok, Maryla, Vigar, Miriam Ann, Wagenaar-Bos, Ineke, King, Rosalind Helen Mary, Morgan, Brian Paul, Baas, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276415/
https://ncbi.nlm.nih.gov/pubmed/18349134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070660
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