M. leprae components induce nerve damage by complement activation: identification of lipoarabinomannan as the dominant complement activator

Peripheral nerve damage is the hallmark of leprosy pathology but its etiology is unclear. We previously identified the membrane attack complex (MAC) of the complement system as a key determinant of post-traumatic nerve damage and demonstrated that its inhibition is neuroprotective. Here, we determin...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Bahia El Idrissi, Nawal, Das, Pranab K., Fluiter, Kees, Rosa, Patricia S., Vreijling, Jeroen, Troost, Dirk, Morgan, B. Paul, Baas, Frank, Ramaglia, Valeria
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405335/
https://ncbi.nlm.nih.gov/pubmed/25772973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1404-5
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