Na(v)1.1 Localizes to Axons of Parvalbumin-Positive Inhibitory Interneurons: A Circuit Basis for Epileptic Seizures in Mice Carrying an Scn1a Gene Mutation

Loss-of-function mutations in human SCN1A gene encoding Na(v)1.1 are associated with a severe epileptic disorder known as severe myoclonic epilepsy in infancy. Here, we generated and characterized a knock-in mouse line with a loss-of-function nonsense mutation in the Scn1a gene. Both homozygous and...

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Vydáno v:J Neurosci
Hlavní autoři: Ogiwara, Ikuo, Miyamoto, Hiroyuki, Morita, Noriyuki, Atapour, Nafiseh, Mazaki, Emi, Inoue, Ikuyo, Takeuchi, Tamaki, Itohara, Shigeyoshi, Yanagawa, Yuchio, Obata, Kunihiko, Furuichi, Teiichi, Hensch, Takao K., Yamakawa, Kazuhiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672241/
https://ncbi.nlm.nih.gov/pubmed/17537961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5270-06.2007
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