Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome

Dravet syndrome is a severe epileptic encephalopathy mainly caused by heterozygous mutations in the SCN1A gene encoding a voltage-gated sodium channel Nav1.1. We previously reported dense localization of Nav1.1 in parvalbumin (PV)-positive inhibitory interneurons in mice and abnormal firing of those...

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Detalhes bibliográficos
Main Authors: Ogiwara, Ikuo, Iwasato, Takuji, Miyamoto, Hiroyuki, Iwata, Ryohei, Yamagata, Tetsushi, Mazaki, Emi, Yanagawa, Yuchio, Tamamaki, Nobuaki, Hensch, Takao K., Itohara, Shigeyoshi, Yamakawa, Kazuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820136/
https://ncbi.nlm.nih.gov/pubmed/23922229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt331
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