Impaired cortico-striatal excitatory transmission triggers epilepsy

STXBP1 and SCN2A gene mutations are observed in patients with epilepsies, although the circuit basis remains elusive. Here, we show that mice with haplodeficiency for these genes exhibit absence seizures with spike-and-wave discharges (SWDs) initiated by reduced cortical excitatory transmission into...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Miyamoto, Hiroyuki, Tatsukawa, Tetsuya, Shimohata, Atsushi, Yamagata, Tetsushi, Suzuki, Toshimitsu, Amano, Kenji, Mazaki, Emi, Raveau, Matthieu, Ogiwara, Ikuo, Oba-Asaka, Atsuko, Hensch, Takao K., Itohara, Shigeyoshi, Sakimura, Kenji, Kobayashi, Kenta, Kobayashi, Kazuto, Yamakawa, Kazuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478892/
https://ncbi.nlm.nih.gov/pubmed/31015467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09954-9
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